South African captain AB de Villiers won the toss and opted to bat in the fifth and final day-night international against Pakistan in Sharjah on Monday.
South Africa, with an unbeatable 3-1 lead, rested pace spearhead Dale Steyn and Morne Morkel as well as spinner Imran Tahir.
They were replaced by Vernon Philander, Wayne Parnell and Robin Peterson.
Pakistan, who lost the first match here by one run, brought back Umar Amin in place of Asad Shafiq.
After this series the two teams play Twenty20 internationals in Dubai on November 13 and 15.
Pakistan: Misbah-ul-Haq (capt), Ahmed Shehzad, Junaid Khan, Mohammad Hafeez, Mohammad Irfan, Saeed Ajmal, Shahid Afridi, Sohaib Maqsood, Sohail Tanvir, Umar Akmal, Umar Amin.
South Africa: AB de Villiers (capt), Hashim Amla, Quinton de Kock, Jean-Paul Duminy, Faf du Plessis, Ryan McLaren, David Miller, Wayne Parnell, Robin Peterson, Vernon Philander, Lanwabo Tsotsobe.
Umpires: Richard Illingworth (ENG) and Ahsan Raza (PAK) TV umpire: Steve Davis (AUS) Match referee: Ranjan Madugalle (SRI)