The airstrikes hit mountainous areas of the Khyber tribal district.
“First jet fighters were used early in the morning and then ground troops were sent to the area,” a senior security official in Peshawar told AFP on condition of anonymity.
Military sources said at least 37 militants were killed and 18 wounded in the operation.
Independent verification of the death toll and identity of the dead was not possible, as journalists are not allowed to enter the area.
Another security official said the strikes targeted militants involved in bomb attacks in the northwestern town of Charsadda and on a fruit and vegetable market in Islamabad which killed 24 people.
Officials said ground troops also used heavy weapons to pound militant targets.