ISLAMABAD: It may be possible to “soften-up” cancers before hitting them with chemotherapy drugs, researchers suggest.
A study uncovered how tumours can become resistant to commonly used drugs.
The University of Manchester team suggest drugs already in development may be able to counter this resistance to make chemotherapy more effective, BBC reported.
The team were looking at a class of drugs called taxanes, which are used to treat a range of cancers.
By studying cancerous cells growing in the laboratory they were able to show how the class of drugs trigger cancer cells to kill themselves.
But at the same time they discovered a key difference between cancers thaT were susceptible to the drugs and those which were inherently resistant, or later developed resistance.
“Potentially combining this with taxanes you could take resistant [cancers] and make them sensitive.
“These new inhibitors would essentially soften-up the cancer cells so when they are treated they are more likely to die.”