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Russian forces have destroyed an ammunition depot at the Myrhorod Air Base in central-eastern Ukraine, Interfax news agency reported on Saturday, quoting Russia's Defence Ministry.

A Ukrainian air force MiG-29 fighter and a Mi-8 helicopter were also destroyed in the attack on the base in the Poltava region, ministry spokesman Igor Konashenkov said.

He added that a large ammunition depot was also destroyed near the city of Novomoskovsk in the central-eastern Dnipro region.

Russia sent tens of thousands of soldiers into Ukraine on February 24 for what it calls a "special military operation" to demilitarise and "denazify" Ukraine.

Ukraine on Saturday called on civilians in the eastern Luhansk region to flee from Russian shelling after officials said more than 50 civilians trying to evacuate by rail from a neighbouring region were killed in a missile attack.

Russia has repeatedly denied allegations of war crimes and denies targeting civilians in Ukraine.

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Governor of the Poltava region, Dmytro Lunin, said on social media that two people had been wounded and "significant damage" caused due to the Russian strike at Myrhorod. He did not give further details.

On April 2, Lunin said a Russian air strike had damaged an airfield runway and fuel depot near the air base.

Konashenkov said on Saturday that Russia has hit 85 military targets in Ukraine, including two command posts, three rocket launchers, four self-propelled artillery guns, an ammunition depot and two logistics depots, among others.

Since Feb. 24, Russian forces have destroyed 650 aircraft, including jets and helicopters, and more than 2,000 tanks and armored vehicles in Ukraine, Konashenkov was quoting as saying by Interfax.

Reuters could not immediately verify the figures provided.

According to estimates by Ukraine's Defence Ministry, 19,100 Russian personnel have been killed since the start of the invasion. It says Russia has lost 705 tanks, 1,895 armoured personnel carriers, 151 aircrafts and 136 helicopters.

Kremlin spokesman Dmitry Peskov said on Thursday that Russia had sustained "significant losses" in Ukraine.

In its most recent update, on March 25, Russia's defence ministry said 1,351 Russian soldiers had been killed since the start of the campaign, and 3,825 had been wounded.